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fmblab

Transcriptomic and Proteomic Analysis of Clear Cell Foci (CCF) in the Human Non-Cirrhotic Liver Identifies Several Differentially Expressed Genes

Dual Effects of Non-Coding RNAs (ncRNAs) in Cancer Stem Cell Biology   The identification of cancer stem cells (CSCs) as initiators of carcinogenesis has revolutionized the era of cancer research and our perception for the disease treatment options. Additional CSC features, including self-renewal and migratory and invasive capabilities, have further justified these cells as putative diagnostic, prognostic, […]

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fmblab

Affects Non-Small-Cell Lung Cancer Cell Biology By Regulating the miR-21/PTEN/AKT

Propofol Affects Non-Small-Cell Lung Cancer Cell Biology By Regulating the miR-21/PTEN/AKT Pathway In Vitro and In Vivo Background: Propofol is a common sedative-hypnotic drug traditionally used for inducing and maintaining general anesthesia. Recent studies have drawn attention to the nonanesthetic effects of propofol, but the potential mechanism by which propofol suppresses non-small-cell lung cancer (NSCLC) progression has not been fully […]

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fmblab

Rising Novel Coronavirus is a International Menace: Perception within the Biology

Molecular Biology of Basal and Squamous Cell Carcinomas The prevalent keratinocyte-derived neoplasms of the pores and skin are basal cell carcinoma and squamous cell carcinoma. Each so-called non-melanoma pores and skin cancers comprise the commonest cancers in people by far. Frequent danger components for each tumor entities embrace solar publicity, DNA restore deficiencies resulting in chromosomal instability, or immunosuppression. […]

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fmblab

Recent advances in myeloid-derived suppressor cell biology

Entosis: From Cell Biology to Clinical Cancer Pathology Entosis is a phenomenon, in which one cell enters a second one. New clinico-histopathological studies of entosis prompted us to summarize its significance in cancer. It appears that entosis might be a novel, independent prognostic predictor factor in cancer histopathology. We briefly discuss the biological basis of entosis, followed by […]

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fmblab

Dysregulation of club cell biology in idiopathic pulmonary fibrosis

Recent advances in synthetic biology-enabled and natural whole-cell optical biosensing of heavy metals A large number of scientific works have been published on whole-cell heavy metal biosensing based on optical transduction. The advances in the application of biotechnological tools not only have continuously improved the sensitivity, selectivity, and detection range for biosensors but also have simultaneously unveiled […]

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fmblab

Kiss1R identification and biodistribution analysis utilizing a western ligand blot

Kiss1R identification and biodistribution analysis utilizing a western ligand blot and ligand-derivative stain with a FITC-kisspeptin by-product   It isn’t always easy to determine explicit antibodies in opposition to receptors. Most receptors are hydrophobic and have tough three-dimensional constructions, making them powerful to utilize as immunogens. Thus, we developed receptor detection methods with a fluorescein-labeled ligand as an antibody […]

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fmblab

Enchancment of immunodetection of the transcription issue C/EBP homologous protein

Enchancment of immunodetection of the transcription issue C/EBP homologous protein by western blot. Accumulation of misfolded proteins throughout the endoplasmic reticulum (ER) induces an unfolded protein response (UPR) that both restores homeostasis or triggers apoptosis in case of adaptation failure. The three activated branches of UPR result in IRE1-, PERK- and ATF6– dependent transcriptional induction of the […]